IRDye® 800CW EGF Optical Probe (20 nmol)


IRDye 800CW EGF Optical Probe is a near-infrared (NIR) fluorescently-labeled recombinant human epidermal growth factor (EGF). This optical imaging agent is composed of a recombinant EGF polypeptide containing 54 amino acid residues (molecular weight = 6.2 kDa) conjugated to the LI-COR IRDye 800CW infrared dye.

IRDye 800CW EGF provides a versatile probe that can be used for in vitro and in vivo assays, as well as whole organ and tissue section analysis. In vivo assays of EGF binding have proven effective in monitoring specific solid tumor models that exhibit overexpression of EGFR.

Epidermal growth factor receptor (EGFR) is one of a family of receptor tyrosine kinases found on the surface of epithelial cells, to which EGF binds. Many types of cancer cells have abnormally high EGFR levels on the cell surface (table below).

Saadaval järeltellimisel

Tootekood: 926-08446 Kategooriad: ,
Tumor Type % of Tumors Over-Expressing EGFR
Head and Neck 80-100
Renal Cell 50-90
Non-small-cell Lung 40-80
Glioma 40-63
Ovarian 35-70
Bladder 31-48
Pancreatic 30-50
Colon 25-77
Breast 14-91
Kaal 0,002 kg

20 nmol

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